CRPC-TR99791 April 1999 Title: The Bayesian Statistical Approach to the Phase Problem in Protein X-ray Crystallography Authors: Zhijun Wu, George Phillips, Richard Tapia, and Yin Zhang Submitted November 1999 Abstract: We review a Bayesian statistical approach to the phase problem in protein X-ray crystallography. We discuss the mathematical foundations and the computational issues. The introduction to the theory and the algorithms does not require strong background in X-ray crystallography and related physical disciplines. ------------------------------------------------------------------------------ Zhijun Wu zwu@caam.rice.edu Department of Biochemistry and Cell Biology Rice University George Phillips georgep@rice.edu Department of Computational and Applied Mathematics Rice University Richard Tapia rat@caam.rice.edu Department of Computational and Applied Mathematics Rice University Yin Zhang zhang@caam.rice.edu Department of Computational and Applied Mathematics Rice University